Myelomatosis--Fundamentals and Clinical Features

Fundamentals of Clinical Immunology

THIS text book was originally published in 1970 in two volumes and the authors have found it necessary to increase the number of volumes to four. They fear that this may make it a reference work rather than a text book. I am afraid that this is inevitable in a four volume series but that does not make it any the less important in my view. In any case I consider all text books, except the most c...

Plasma Cell Myelomatosis

Frictional melanosis and its clinical and histopathological features

Background: A rippled type of pigmentation is observed on the arms, forearms, and bony prominences, more commonly in women with a history of chronic rubbing. The terminology (commonly referred to as frictional melanosis) and its relation with cutaneous amyloidosis has been debated. Materials and Methods: Twenty one patients with pigmented skin lesions with manifestations suggestive of frictiona...

The fundamentals of clinical discovery.

There is a widespread view that clinical research is failing to advance appropriately, particularly in comparison with other aspects of biomedical science. I argue that this is due in part to an inadequate understanding of how medical advance occurs. The common usage of such terms as basic or fundamental, or the uncritical use of the term model is unhelpful--unhelpful, in that such terms tend t...

Fundamentals of clinical trial design.

Most errors in clinical trials are a result of poor planning. Fancy statistical methods cannot rescue design flaws. Thus careful planning with clear foresight is crucial. Issues in trial conduct and analyses should be anticipated during trial design and thoughtfully addressed. Fundamental clinical trial design issues are discussed.